Abstract P377: Prevalence of Carotid Plaque and Cardiovascular Risk Factors Among 40-49 Year Old White, Japanese American, Japanese in Japan and Korean Men from the ERA JUMP Study
Objective: Carotid atherosclerotic plaque is an independent predictor of stroke and coronary heart disease. Few studies have reported differences in the prevalence of carotid plaque across multiple racial/ethnic groups.
Methods: The ERA JUMP Study is an international population-based study of subclinical atherosclerosis in men aged 40-49 years without clinical CVD including 310 whites (W) in Allegheny County, PA, US, 302 Koreans in Ansan, South Korea (K), 303 Japanese Americans (JA) in Honolulu, HI, US and 313 Japanese in Kusatsu, Shiga, Japan (JJ). Baseline exam included measurement of traditional CVD risk factors and B-mode carotid ultrasound scan. The Ultrasound Research Laboratory in Pittsburgh trained sonographers at each site to standardize the carotid ultrasound measures. Carotid plaque was assessed bilaterally from the proximal common carotid artery to the proximal internal carotid artery, and de[[Unable to Display Character: ﬁ]]ned as a distinct area protruding into the vessel lumen that was at least 50% thicker than the adjacent intima-media. Logistic (presence) and Poisson (number of plaque) regression were used to examine the association of CVD risk factors with plaque.
Results: About half of JA (48.1%) had carotid plaque present on ultrasound exam. In contrast, prevalence of plaque among JJ was 4.8%, while among Koreans it was 10.6%(Table). Logistic regression showed that age, hypertension, diabetes, hyperlipidemia, current smoking and body-mass index were positively associated with plaque but most associations did not reach statistical significance. Poisson regression showed age (all groups), diabetes (W, K), hypertension (W), and smoking (JA) were significant predictors for number of plaque. Among those without diabetes and hypertension, prevalence of plaque was 47.1% (JA), 4.6% (JJ), 22.4% (W) and 8.6% (K).
Conclusions: JA had 10 fold higher prevalence of carotid plaque than JJ. A cross-sectional difference in risk factors does not appear to account for the difference in the prevalence of carotid plaque among racial/ethnic groups.
- © 2013 by American Heart Association, Inc.