Abstract P364: Clinical Determinants of Left Ventricular Structure Determined by Cardiac Magnetic Resonance Imaging: The Jackson Heart Study
Introduction: Cardiac MRI (CMRI) delivers high-resolution images with accurate and reproducible measurements of left ventricular (LV) structure (LV mass, systolic volume and diastolic volume) that are known predictors of MI, stroke, and death. There is limited data regarding the distribution and clinical determinants of CMRI-derived variables of LV structure in a community-based cohort of African Americans (AAs).
Hypothesis: We hypothesize that age, sex, hypertension (HTN), and obesity are associated with variability of LV mass and volumes by CMRI in AAs.
Methods: We evaluated 1,322 Jackson Heart Study participants [63% (832 of 1322) women, mean age 57 years] who had MRI exams performed at Examinations 2 and 3. Measures of LV structure included LV mass, systolic volume, and diastolic volume. Clinical covariates included age, sex, systolic and diastolic BP, BMI, fasting glucose (FG), diabetes status, lipids, smoking, alcohol use, HTN and lipid lowering medication, education and income. Multiple stepwise linear regression analysis was used to model the association of clinical covariates (independent variables) with measures of LV structure.
Results: For our study, mean (SD) for LV mass, diastolic and systolic volumes were 117.8 (27.8) grams, 113.2 (31.0) ml and 40.2 (18.9) ml respectively in women and 166.7 (32.7) grams, 135.9 (30.6) and 54.1 (30.2) mL respectively in men. All three cardiac parameters were significantly greater in men (P<0.0001). In the regression analysis, 32%, 9% and 9% of the total variability in LV mass, LV diastolic and LV systolic volume were explained by sex. Sex-specific results of the regression analysis are shown on Table1.
Conclusions: In our cross-sectional study of a large AA community-based cohort, we identified several CV risk factors (including sex, age, BMI, systolic BP, FG, alcohol and smoking) that contribute significantly to the variability of CMRI-derived LV structure.
- © 2013 by American Heart Association, Inc.