Abstract P363: Cross-Sectional Comparison of Coronary Artery Calcium Prevalence between Japan and the US: The Multi-Ethnic Study of Atherosclerosis (MESA) and the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)
Background: Recent literature has shown that the burden of certain coronary risk factors, such as blood pressure and total cholesterol, has become comparable between the US and Japan in the past decades. We investigated whether levels of coronary artery calcium (CAC), a marker of coronary atherosclerosis, are similar between the two countries after accounting for conventional risk factors.
Method: We cross-sectionally investigated community-based samples of White men from six sites in the US from 2000 to 2002 (the Multi-Ethnic Study of Atherosclerosis: MESA), and of Japanese men from Kusatsu City, Shiga, Japan from 2006 to 2008 (Shiga Epidemiological Study of Subclinical Atherosclerosis: SESSA), aged 45 to 74 years and free of cardiovascular disease. Based on the presence of the following five risk factors, we categorized participants into groups with 0, 1, 2, or ≥3 risk factors: current smoking, overweight (defined as body mass index ≥25kg/m2), diabetes mellitus (fasting glucose≥126mg/dL or medication), dyslipidemia (LDL-c≥160mg/dL or HDL-c<40mg/dL or medication), and hypertension (systolic/diastolic blood pressure ≥140/90mmHg or medication). Proportions of Agatston score of 0-99, 100-399, and ≥400 were assessed according to the number of risk factors among three age groups (45-54, 55-64, and 65-74 years).
Results: Of 1,067 White men (mean age 60.0 [± SD 8.5] years) and 834 Japanese men (63.3 [±7.5] years) studied, 9.7% of the White men and 14.1% of the Japanese men had 0 risk factors, whereas 28.0% of the former and 21.3% of the latter had ≥3 risk factors. Overall, prevalence of an Agatston score of ≥100 or ≥400 was greater in White men across all the risk strata in the three defined age groups, particularly among those aged 55-64 and 65-74 years (Figure).
Conclusion: Compared to Japanese men, White men in the US tend to have a higher burden of coronary atherosclerosis, as measured by CAC, regardless of the number of present conventional risk factors. This was most evident among those aged 55-74 years.
- © 2013 by American Heart Association, Inc.