Abstract P334: Blood Pressure Salt Sensitivity Influences Plasma Glucose Response to Dietary Sodium and Potassium Intervention
We studied the association between blood pressure salt sensitivity and plasma glucose responses to dietary sodium intervention among 1,906 GenSalt (Genetic Epidemiology Network of Salt Sensitivity) study participants in rural China. The dietary intervention included a 7-day low-salt feeding (51.3 mmol/day), a 7-day high-salt feeding (307.8 mmol/day), and a 7-day high-salt feeding plus potassium supplementation (60 mmol/day). Overnight fasting blood samples were drawn by venipuncture at the baseline examination and at the 6th day of each of the intervention periods. Plasma glucose was measured using a modified hexokinase enzymatic method. Mean levels (SD) of fasting plasma glucose were 87.1 (12.9), 90.4 (11.9), 85.7 (11.3), and 85.0 (12.0) mg/dL for the baseline, low-sodium feeding, high-sodium feeding, and high-sodium feeding plus potassium supplementation periods, respectively. There was a significant association between changes in mean arterial pressure and fasting plasma glucose levels during dietary sodium and potassium interventions. Each mm Hg increase in mean arterial pressure from the low-sodium to high-sodium diets was associated with a 0.1 mg/dL increase in fasting plasma glucose (p=0.001). In addition, each mm Hg increase in mean arterial pressure from the high-sodium to high-sodium plus potassium supplementation diets was associated with a 0.1 mg/dL increase in fasting plasma glucose (p=0.003). In conclusion, salt sensitivity of blood pressure modifies glucose responses to dietary sodium and potassium intake. The clinical significance of this interrelationship among blood pressure and glucose responses to dietary sodium and potassium intake requires further investigation.
- © 2013 by American Heart Association, Inc.