Abstract P330: Inverse Association between Adult Height and Risk of Hypertension in the Physicians’ Health Study
Background: Mechanisms underlying the reported inverse relation between height and cardiovascular disease (CVD) are not well clarified. In particular, it is not known whether adult height influences the future risk for hypertension (HTN). We therefore tested the hypothesis that height is inversely related to the risk of incident HTN.
Methods: We prospectively followed 16,537 non-hypertensive male physicians (mean age, 52 years) from the Physicians’ Health Study who were initially free of CVD. Adult height was self-reported at baseline, along with other coronary risk factors. Incident HTN was ascertained through follow-up questionnaires and was defined as either the initiation of anti-hypertensive treatment, self-reported systolic blood pressure (BP) ≥140 mm Hg, or diastolic BP ≥90 mm Hg. We used Cox regression to estimate hazard ratios (HRs) adjusted for age, weight, cigarette smoking, alcohol consumption, exercise, parental history of myocardial infarction before the age of 60 years, diabetes mellitus, and high blood cholesterol or cholesterol treatment.
Results: The mean height ± SD was 1.79 ± 0.07 m at baseline. During a median follow-up of 19 years, 7,649 new cases of HTN were reported. Multivariable adjusted HRs (95% CI) for incident HTN were 1.00 (ref), 0.91 (0.85-0.97), 0.78 (0.73-0.84) and 0.74 (0.68-0.81) across increasing quartiles of height (p for linear trend < 0.0001). The HR per SD increase in height was 0.88 (0.85-0.91). In a secondary analysis of 11,722 participants with self-reported measurements of waist circumference (WC) obtained 9 years after baseline examination, height was inversely associated with incident HTN in the first 3 quartiles of WC but not in the 4th quartile (≥102.2 cm; p for interaction 0.02) (Figure 1).
Conclusion: Adult height was inversely associated with incident HTN in male physicians. A sub analysis in participants with available data on WC showed similar findings in men with WC <102.2, but not among subjects with WC ≥102.2 cm.
- © 2013 by American Heart Association, Inc.