Abstract P325: Predictors of High Pulse Pressure and Change in Pulse Pressure with Age in the Atherosclerosis Risk in Communities (ARIC)Study
Introduction Pulse pressure (PP), an indirect measure of arterial stiffness, is a strong predictor of CVD risk. Determinants of PP and change in PP with age are not well described.
Methods In a population-based cohort of 10,854 white and African-American men and women 44 - 66 years of age (mean 53.6 years) not taking anti-hypertensive therapy, SBP and DBP were measured at 4 visits 3 years apart (average 3.4 visits per person). At each visit three readings were taken using a random-zero sphygmomanometer and the average of the last two values computed.
Results In a random effects linear model the average annual change in PP was 1.09 mm Hg (SE 0.02, P <.0001), after accounting for baseline age differences. Race, sex, diabetes, smoking, drinking, and BMI were statistically significant predictors of average PP at any time point, but total and HDL cholesterol were not (Table). Diabetes, the most influential predictor, increased the average PP at any time point by 4.86 mm Hg (SE 0.41). Current (but not former) drinking was the only risk factor associated with a decrease in the average PP at any time point, by 1.05 mm Hg (SE 0.23). In addition, diabetes (women only) and BMI (women only) were associated with an increase, and current drinking with a decrease, in the average annual rate of change in PP.
Conclusion In this middle-aged cohort, diabetes, BMI, and current drinking are important determinants of both the absolute level of PP and the annual rate of change in PP with age.
- © 2013 by American Heart Association, Inc.