Abstract P322: Adipokines are Independently Associated with Renin and Aldosterone - The Multi-ethnic Study of Atherosclerosis
Background: Obesity is an independent risk factor for hypertension (HTN). This study tested the hypothesis that leptin (LEP) would be significantly associated with higher levels of renin (REN) and aldosterone (ALDO), while adiponectin (ADP) would be associated with lower levels of these regulators of blood pressure.
Methods: Subjects were 1970 individuals without clinical CVD at baseline who were enrolled in the Multi-Ethnic Study of Atherosclerosis and evaluated by collection of extensive survey information, relevant physical measurements and fasting venous blood that was analyzed for the adipokines adiponectin and leptin, as well as plasma renin activity and aldosterone levels.
Results: The mean age was 64.7 years, 50% were female and 44% had HTN. The mean body mass index was 28.2 and 31% were obese. Average (SD) values for ADP, LEP, REN and ALDO were 20.7 (13.1) μg/ml, 20.9 (22.3) ng/ml, 1.44 (3.33) ng/ml and 150.1 (86.9) pg/ml, respectively. From multivariable linear regression, higher LEP was associated with significantly higher REN and ALDO levels, while higher ADP was associated with higher ALDO but not REN levels (Table). Notably, when REN was included to the final model, the associations between both adipokines and ALDO remained significant. The results were similar (albeit somewhat attenuated) when the analyses were restricted to those not taking a BP medication.
Conclusion: Higher ADP and LEP are significantly associated with higher ALDO and/or REN levels independent of relevant covariates, to include REN when ALDO is the outcome variable. The findings suggest these adipokines may be independently contributing to the pathogenesis of blood pressure regulation by the kidney.
- © 2013 by American Heart Association, Inc.