Abstract P315: Epidemiology of Chronic Kidney Disease in Italy: The National Health Examination Surveys 2008-2012
Background: The epidemic dimensions of non-dialysis chronic kidney disease (CKD) and the associated elevated cardiovascular (CVD) risk as well as the high costs of renal replacement therapy have made the identification of CKD patients and the quantification of CKD-related comorbidities a key priority in the strategies of public health worldwide. No study however has adequately addressed these questions at national level in Europe.
Methods: CKD prevalence and its association with CVD in Italy was assessed using data of the CARHES Study within the Health Examination Survey/Osservatorio Epidemiologico Cardiovascolare (HES/OEC) 2008-2012. Random samples of general population stratified by age and sex were examined in all Italian regions (220 persons from each 1,5 million of resident population; participation rate 56%). In 3349 men and 3328 women aged 35-79 years, CKD was assessed by Kidney Disease Outcomes Quality Initiative stages. Biochemical tests were assayed in a central laboratory. Glomerular Filtration Rate (eGFR) was estimated by gold standard method (enzymatic assay of serum creatinine and CKD-EPI equation). Comparisons between men and women were assessed using t-test.
Results: Mean value of eGFR was 95.7 ml/min/1.73m2 in men (95.1-96.4 ml/min/1.73m2) and 96.8 ml/min/1.73m2 in women (96.2-97.3). Prevalence of CKD resulted 8.1% in men (7.2-9.2 %) and 7.9 in women (7.0-8.8 %). Of 535 persons with CKD, 201 (38%) had eGFR <60 mL/min/1.73 m2, 334 (62%) had eGFR ≥60 mL/min/1.73 m2 and albuminuria creatinine ratio ≥ 30 mg/g (of these 44 persons with albuminuria creatinine ratio ≥300 mg/g). Prevalence of CKD by area was: 7.4% in men and 8.1 in women in North, 6.8 e 6.7 respectively in Centre, 9,4% e 8.1% respectively in South of Italy. In persons with CKD, albuminuria, fasting glucose, triglycerides, systolic blood pressure and body mass index were higher while levels of total and HDL cholesterol were lower. Prevalence of hypertension and obesity resulted higher in persons with CKD than in those without.
Conclusions: In Italy we found that prevalence of CKD is high even though lower versus other countries. Means level of CVD risk factors and prevalence of high risk conditions resulted higher in those with CKD. This information will increase the awareness of CKD and related risks among Italian physicians and health authorities.
- © 2013 by American Heart Association, Inc.