Abstract P307: Relation of Serum Leptin and Adiponectin Level to Serum C-Reactive Protein of Japanese in Japan and Japanese-Americans in Hawaii: The INTERLIPID Study
Background Leptin and adiponectin, secreted by adipose tissue, represent the most abundant adipokines in human serum. Despite considerable study, the relevance of leptin and adiponectin in atherosclerosis development is still unsettled. We investigated relation of serum leptin and adiponectin to serum C-reactive protein (CRP), a marker of atherosclerosis, using the INTERLIPID dataset on Japanese emigrants living in Hawaii and Japanese in Japan.
Methods Serum leptin, adiponectin, and CRP were examined by standardized methods in men and women ages 40 to 59 years from two population samples, one Japanese-American in Hawaii (98 men, 104 women), the other Japanese in central Japan (114 men, 104 women). Participants with CRP >10 mg/L were excluded.
Results Across quartiles of serum CRP, mean BMI, and median leptin were significantly higher, and median adiponectin was significantly lower in the higher CRP groups for both sexes (trend Ps <0.01). Mean SBP was significantly higher in the higher CRP groups in women (Table). Sex-specific multiple linear regression analyses with log-transformed leptin and adiponectin (log-leptin, log-adipo), site (Hawaii=1, Japan=0), SBP, HbA1c, smoking (cigarettes/day), and physical activity index score of the Framingham Offspring Study as covariates, showed that log-leptin directly related, and log-adipo inversely related to log-CRP for both sexes (Ps<0.05 to <0.01). Addition of BMI and the interaction terms (BMIxlog-leptin, BMIxlog-adipo, SITExlog-leptin, SITExlog-adipo) to the model resulted in disappearance of statistical significance except for direct relation of log-leptin to log-CRP in men (P=0.006).
Conclusions Leptin related to CRP independent of BMI in men.
- © 2013 by American Heart Association, Inc.