Abstract P285: Association between Fibrinogen and Carotid Intima-Media Thickness by Smoking Status
Purpose: Fibrinogen level has been inconsistently associated with carotid intima-media thickness (IMT) in the literature. Cigarette smoking can affect the fibrinogen-IMT association, because smoking is associated with increased fibrinogen level as well as atherosclerosis. Therefore we investigated association between fibrinogen and IMT by smoking status in a Korean male population.
Methods: Plasma fibrinogen level was measured in 277 men, aged 40-87 years, without history of myocardial infarction or stroke. Common carotid arteries were ultrasonographically examined. IMT level was analyzed both as a continuous (IMT-max, maximum value; IMT-tpm, 3-point mean value) and categorical variable (plaque, defined as IMT-max >1.0 mm or focal wall thickening >100%). Serial linear and logistic regression models were employed to assess independent association between fibrinogen and IMT by smoking status.
Results: Fibrinogen level was positively associated with IMT-max (standardized ß = 0.25, p=0.021) and IMT-tpm (standardized ß = 0.21, p=0.038) even after adjustment for age, body mass index, systolic blood pressure, fasting glucose, and total cholesterol to HDL-cholesterol ratio in current smokers (n=75). However, there was no significant association between fibrinogen and IMT in former smokers (n=80) and nonsmokers (n=122). Adjusted odds ratio (95% confidence interval) for having plaque per one standard deviation higher fibrinogen level was 2.06 (1.09 to 3.89) in current smokers, 0.68 (0.42 to 1.10) in former smokers, and 1.06 (0.60 to 1.87) in nonsmokers.
Conclusions: Our findings suggest that cigarette smoking may modify the association between fibrinogen and carotid atherosclerosis. Further studies are required to confirm this finding in diverse populations.
- © 2013 by American Heart Association, Inc.