Abstract P275: Racial Differences in the Association of Serum 25-hydroxyvitamin D Concentration with Coronary Heart Disease Events
Background Lower serum 25-hydroxyvitamin D (25(OH)D) concentrations are consistently associated with coronary heart disease events (CHD) and all-cause mortality; however, the majority of previous studies have assessed only White populations.
Methods We studied 6,426 participants from the Multi-Ethnic Study of Atherosclerosis (mean age 62 years) who were free of known cardiovascular disease at baseline. We measured 25(OH)D concentrations using a mass-spectrometry assay calibrated to national standards. We used proportional hazards models to evaluate adjusted associations of baseline serum 25(OH)D with the time to first myocardial infarction, angina, cardiac arrest or CHD death among White, Black, Chinese and Hispanic participants.
Results During a median of 7.6 years of follow-up, 318 (5%) participants developed an incident CHD event. Observed association of 25(OH)D with CHD significantly differed by race/ethnicity (p-for interaction=0.02). After adjustment, every 10ng/mL decrement in serum 25(OH)D concentrations was associated with an estimated 31% greater risk of incident CHD in White participants (95% CI: 1.10,1.56) and a 76% greater risk in Chinese participants (95% CI: 1.10, 2.84). In contrast, lower 25(OH)D concentration was not associated with the risk of CHD in Black or Hispanic participants (HR (95%CI):0.93 (0.71, 1.21) and 0.96 (0.76, 1.29), respectively).
Conclusions In a large multi-ethnic study population that was free of cardiovascular disease, lower serum 25(OH)D concentrations are associated with incident CHD events in White and Chinese individuals, but not in Blacks or Hispanics. Extrapolation of findings from ethnically homogeneous populations may not be appropriate.
- © 2013 by American Heart Association, Inc.