Abstract P271: The Association of Lifestyle Factors with Circulating Levels of the Soluble Receptor for Advanced Glycation End Products (sRAGE): The Atherosclerosis Risk in Communities (ARIC) Study
Introduction. Accumulation of advanced glycation end products (AGEs) is hypothesized to contribute to oxidative stress, vascular inflammation, and atherosclerosis. The soluble form of the receptor for AGEs (sRAGE) may act as a “sponge” for AGEs and is lower in persons with vascular damage (e.g., individuals with CVD). Influenced by endogenous factors, low sRAGE may also be determined by modifiable factors including tobacco use and lifestyle behaviors. Previous literature also suggests that intake of foods with high AGE content might be important contributors to AGE accumulation in the body. This study aimed to evaluate the association of major lifestyle factors with serum sRAGE levels in the Atherosclerosis Risk in Communities (ARIC) Study.
Methods. We conducted a cross-sectional analysis of 2,482 participants aged 47-68 years with measured sRAGE at ARIC Visit 2 (1990-1992); participants were selected based on estimated GFR values (>60 mL/min/1.73m2) and individuals with missing data for the variables of interest were excluded. Multivariable logistic regression was used to examine associations with low levels of sRAGE (lowest quartile: 119.4-725.3 pg/mL). Lifestyle factors included adiposity, smoking, alcohol consumption, high AGE-content food intake, and physical activity.
Results. Smoking, alcohol use, and body mass index were strongly associated with low sRAGE (Table). Consumption of high AGE-content foods was also weakly associated with low sRAGE. Physical activity was not associated after multivariable adjustment.
Conclusions. Modifiable behaviors, such as smoking and alcohol use, were associated with sRAGE levels. Additionally, higher body mass index may contribute to low sRAGE levels. Further studies that examine the effects of changes in these factors would provide information about whether sRAGE levels are modified by changes in lifestyle factors over time.
- © 2013 by American Heart Association, Inc.