Abstract P251: Insulin Resistance Independently Predicts Oxidized Low-Density Lipoprotein in Latino Youth
Introduction: Obesity and insulin resistance are associated with increased risk for cardiovascular disease (CVD), but the underlying mechanisms are not clear. Data in adults suggest that markers of oxidative stress, including circulating levels of oxidized low-density lipoprotein (oxLDL), are associated with obesity and may contribute to the athrogenic process. Whether insulin resistance independently contributes to higher oxLDL levels in youth is unknown. Therefore, the purpose of this study was to test the hypothesis that insulin resistance predicts oxLDL levels independent of obesity among Latino youth.
Methods: One hundred and twenty-four Latino youth One hundred and twenty-four Latino youth (F=75; M=49; Lean=62, Overweight=32, Obese=30) participating in the Maricopa County Insulin Resistance Registry, designed to study CVD and diabetes risk factors in the Latino population, were used for this analysis. Participants were assessed for fasting levels of oxLDL via sandwich ELISA (Mercodia, Inc.) and estimates of insulin sensitivity using a multiple sample oral glucose tolerance test to calculate the Matsuda Insulin Sensitivity Index.
Results: Bivariate correlation revealed that both insulin sensitivity and BMI were associated with oxLDL (r=-0.27; p=0.002, and r=0.36; p<0.001, respectively). When insulin sensitivity and BMI were entered into a multivariate regression analysis along with age and gender, insulin sensitivity was a significant independent predictor of oxLDL (β=-0.19; p=0.04; R2= 0.14), whereas BMI was not (β=0.18; p=0.07).
Conclusions: Our findings suggest that insulin resistance may contribute to the atherosclerotic process in youth through a mechanism associated with oxLDL production. Moreover, this process may be independent of obesity. To our knowledge, this is the first study to show that insulin resistance is an independent predictor of higher oxLDL concentrations in youth. Further research is needed in order to determine if improvements in insulin sensitivity result in corresponding improvements in oxLDL levels in this population.
- © 2013 by American Heart Association, Inc.