Abstract P241: Antenatal Betamethasone Exposure Increases Oxidative Stress in African-American Adolescents Born Prematurely
Antenatal glucocorticoids administered to expectant mothers in jeopardy of pre-term delivery are reported to have detrimental effects on kidney development and function in the offspring. Indeed, African-Americans experience a disproportionately higher incidence of pre-term birth, hypertension and chronic kidney disease compared to their Caucasian counterparts. As oxidative stress has been linked to the development of renal disease, the current study determined levels of the oxidative stress marker 8-isoprostane in the urine of African American (AA) adolescents who were born prematurely (<32 weeks gestation) and exposed in utero to betamethasone (BMX; N = 22), born prematurely but not exposed (PRE; N = 32) or born at term (>37 weeks; N = 19). Urinary 8-Isoprostane was determined by ELISA and normalized to urinary creatinine levels. In comparison to term AA, urinary 8-Isoprostane tended to be higher in PRE [1.5 + 0.3 vs. 2.0 + 0.2 pg/g creatinine; P = 0.07], but was significantly greater in the BMX cohort [2.4 + 0.4 pg/g creatinine; P = 0.03]. Oscillometric blood pressure percentiles (BPpct) were determined according to age and height. Systolic BPpct was significantly higher in PRE [51 + 4; P<0.05] and BMX [43 + 6; P<0.05] than term AA [23 + 3]. No difference in systolic BPpct was observed between PRE and BMX [P = 0.12]. Our findings in this cohort suggest that increases in oxidative stress may occur despite further alterations in BP at this age. In summary, we show that antenatal BMX exposure is associated with increases in urinary levels of the oxidative stress marker 8-Isoprostane and systolic BP that may play a role in the development of hypertension and renal disease in adulthood. These findings suggest that early monitoring for individuals exposed prenatally to glucocortiocoids may be helpful in reducing the health disparities experienced by the AA population.
- © 2013 by American Heart Association, Inc.