Abstract P235: Differences in Dyslipidemia Subtypes among Asian American Subgroups Compared to Non-Hispanic Whites
Introduction: Asian Americans are a rapidly growing minority population in the U.S. Higher rates of coronary heart disease (CHD) have been found for some Asian American subgroups, including Asian Indians and Filipinos. Little is known about differences in rates of dyslipidemia, a CHD risk factor, among Asian American subgroups, compared to Non-Hispanic Whites (NHW).
Objective: To compare the differences in prevalence rates of dyslipidemia subtypes (defined below) across Asian American subgroups (Asian Indian, Chinese, Filipino, Japanese, Korean, Vietnamese) compared to (NHW) in a large, mixed payer ambulatory care setting in Northern California.
Methods: We examined the electronic health records of patients age>=35 years with at least one primary care visit from 2008-2011 (N= 53,371 Asian and 109,986 NHW). Age- and sex- adjusted prevalence rates of dyslipidemia subtypes were determined using abnormal laboratory values: High LDL-C (≥ 130mg/dL), low HDL-C (<40 (men) and < 50 (women) mg/dL), and high triglycerides (TG) (≥150 mg/dL). Odds ratios were calculated using multivariate logistic regression, controlling for patient characteristics (age, sex, insurance, BMI, and smoking).
Results: The majority of Asian American subgroups had lower rates of high LDL-C compared to NHWs (46.2%), ranging from 40.6% for Asian Indians to 52.5% for Vietnamese. Asian Indians and Filipinos had higher prevalence rates of low HDL-C, compared to NHWs (54.2%, 37.0%, vs. 33.1%, p<0.0001). All Asian American subgroups had higher prevalence rates of high TG, compared to NHWs (34.0%), ranging from 38.1% for Chinese to 49.6% for Filipinos. When patient characteristics were controlled for the results generally remained the same, with higher odds of low HDL and high TG for the majority of subgroups, particularly for Asian Indians (Low HDL OR=3.4, 95% CI: 3.3-3.5; High TG: 2.5, 2.4-2.6).
Conclusions: The majority of Asian American subgroups, particularly Asian Indians, have higher prevalence rates of low HDL-C and high TG, but lower prevalence rates of high LDL-C, compared to NHWs. Current treatment of dyslipidemia focuses on control of LDL-C, with evidence-based options lacking for low HDL-C and high TG. More research is needed to guide lipid treatment for Asian Americans.
- © 2013 by American Heart Association, Inc.