Abstract P197: Sleep Variability and Cardiac Arrhythmia in Adolescents - Penn State Child Cohort (PSCC) Study
Objectives: To assess the relationship between habitual sleep time and its variability and cardiac arrhythmia in a population-based sample of adolescents.
Methods: We used available data from the first 300 adolescents who have completed the follow up examinations in the population-based PSCC study. We used actigraphy to assess sleep time for 8 consecutive nights. Excluding the first night, we calculated each participant’s 7-night mean sleep time, and its standard deviation. The latter was used as a measure of sleep time variability. Arrhythmia, predominantly premature ventricular complex (PVC), was assessed using a 39-hour high resolution Holter system. The PVC data were analyzed as number of PVCs per hour on an hourly basis (39 hourly repeated measures). Negative binomial regression models were used to assess the sleep and PVC relationships.
Results: The mean age was 17.2 yrs (SD=2.06), with 56% male and 78% white. The average PVC count was 0.75/hr (ranging 0-327, SD=4.84). 7-night mean sleep time and sleep time variability were 6.89 hrs (SD=0.82) and 1.22 hrs (SD=0.60), respectively. The age, race, and sex-adjusted risk ratio (RR) for a one SD increase in the mean sleep time and sleep time variability are presented in Table 1. In summary, a 0.60 hr increase in sleep time variability is associated with a 50% higher PVC frequency (RR=1.50, 95% CI (1.03, 2.18), p = 0.03) in this population-based adolescent sample.
Conclusion: There is a significant adverse association between night-to-night sleep variability and the frequency of premature ventricular complex in healthy adolescents.
- © 2013 by American Heart Association, Inc.