Abstract P188: Cigarette Smoking Increases Low Density Lipoprotein and Inhibits the Decline in Plasma Cholesterol Following Cessation of Alcohol Consumption
Background: Smoking and heavy alcohol consumption are risk factors for cardiovascular disease (CVD). Stopping smoking and reducing alcohol consumption are both related with a reduced in CVD risk although mortality and morbidity attributable to CVD is lower in light-to-moderate drinkers compared with abstainers. Little is known about combined effect of smoking and alcohol on cardiovascular risk. Dyslipidemia, in terms of elevated LDL as well as decreased HDL concentrations, is independently linked to the progression of CVD. Since both alcohol and tobacco smoke can directly influence dyslipidemia, it is of interest to determine how both factors can modify this association. Additionally, the time delay between alcohol cessation and the changes in blood lipids is still unknown.
Hypothesis: We assessed the hypothesis that plasma lipid levels in smoking and non-smoking subjects addicted to alcohol would change following cessation of heavy drinking.
Methods: Subjects were recruited from individuals who participated in an inpatient addiction program following alcohol detoxification. Each subjects provided three blood samples: at baseline, after 3 weeks, and after 6 weeks of treatment. Plasma samples were analyzed for lipids by manual precipitation and automatic enzymatic methods. Changes in plasma lipid concentrations were analyzed using two-way analysis of variances with repeated measures with smoking status as between-subjects factor and time post alcohol cessation as within-subject factors. All analyses were adjusted for sex, age, and BMI and followed by a post hoc Dunnett’s test.
Results: We assessed changes in plasma lipids in 221 subjects (74.7% smokers, aged 45.5±8.1 years, 83.7% male, mean BMI 24.1±3.8). Results are presented on Figure 1.
Conclusions: In conclusion, cigarette smoking increased LDL and inhibited the decline in plasma cholesterol among subjects addicted to alcohol following cessation of heavy drinking.
- © 2013 by American Heart Association, Inc.