Abstract P181: Long-term Exposure to Air Pollution and Risk of Systemic Inflammation-induced Multimorbidity among the Elderly: Results from the Population-based KORA-Age Study
Background: Traffic-related exposure to air pollution is suggested to have adverse health effects on several chronic diseases including cardiovascular disease. However, studies on the association between air pollution and multimorbidity are lacking.
Methods: Applying land use regression models, the average concentrations of six air pollutants (NOx NO2, PM10, PM2.5, PMcoarse, PM2.5abs) were estimated at the residential addresses of 3,661 individuals aged 65-94 years who participated in the 2008/2009 KORA-Age Study in Augsburg and two adjacent counties. Multimorbidity was defined as having ≥ 2 chronic conditions related to systemic inflammation (heart disease, stroke, diabetes mellitus, hypertension, joint disease, kidney disease). Multivariable logistic regression was used to examine the association between air pollution and multimorbidity.
Results: Multimorbidity was prevalent in 38.1% participants, and the mean age of the study population was 73.3 (±6.0) years. In the fully-adjusted model (covariables: age, sex, smoking status, education, marital status, income, physical activity, nutrition score, passive smoking), the risk of multimorbidity was significantly associated with NO2, NOX, and PM10 (see Table 1). Relations between these air pollutants and multimorbidity were not modified by sex, smoking, body mass index, education, residential area or physical (p for interaction>0.05). When analyzing the six chronic diseases separately, only one significant association was found between stroke and PM10 (p=0.045).
Conclusion: The present study suggests that long-term exposure to NOx, NO2, and PM10 is associated with multimorbidity among the elderly. In view of global population aging and the chronic disease burden that is associated with increasing life expectancies around the world, it is imperative to further investigate the role of ambient air pollution in the development of multimorbidity.
- © 2013 by American Heart Association, Inc.