Abstract P133: Effects of Physical Activity and Sedentary Behaviors on Risk of Heart Failure
Background: Heart failure (HF) is a major cardiovascular disease, affecting an estimated 5.7 million American adults with more than 600,000 incident cases occurring each year. It is well known that physical inactivity increases risk of coronary heart disease and stroke morbidity and mortality; prolonged sedentary behavior has more recently been associated with cardiovascular disease outcomes. Few studies have examined the effects of physical inactivity on HF and none have examined the effects of sedentary behaviors.
Methods: The Southern California sample of the California Men’s Health Study, a prospective multi-ethnic cohort study of 39,222 men aged 45 years and older, was used to examine the independent effects of physical activity and sedentary behaviors on HF incidence from 2000 to June 2012. Of these 38,756 were without HF at baseline. A physical activity score was derived from self-reported frequency, duration, and intensity of a list of 17 moderate and vigorous activities. Scores were divided into tertiles. Sedentary behavior was determined from self-reported hours per day outside of work spent watching TV, sitting at a computer, or reading. Covariates were obtained from a self-administered questionnaire. An incident diagnosis for HF was identified through ICD-9 codes from encounters coded in electronic medical records.
Results: The cohort’s race/ethnic breakdown was 62% (23,813 of 38,756) white, 19% (7,249 of 38,756) Hispanic, 9% (3,587 of 38,756) African American, 7% (2,667 of 38,756) Asian, and 3% (1,282 of 38,756) other. Baseline age was 57±7 years, body mass index (BMI) was 28±5 kg/m2; 20% had a high school education or less, 13% were current smokers, and 15% spent 5 or more hours in sedentary activities. Over follow-up (mean 9.7 years; 375,386 person-years) 1,384 men were diagnosed with HF. After controlling for age, race/ethnicity, education, income, BMI, percent calories from fat, alcohol intake, and fruit and vegetable intake and sedentary behavior, participants in the low physical activity category were more likely to be diagnosed with HF than those in the highest physical activity category (HR: 1.52, CI: 1.31, 1.77). Controlling for the same variables and physical activity, participants who were sedentary 5 or more hours per day were more likely to be diagnosed with HF (HR: 1.41, CI: 1.06, 1.88) than those who were sedentary < 1 hour per day.
Conclusion: These data suggest that both low physical activity and high sedentary behaviors may be appropriate intervention targets to prevent HF.
- © 2013 by American Heart Association, Inc.