Abstract P126: Relation of Depressive Symptoms to the Cross-Sectional and Longitudinal Association of Low Cardiovascular Risk with Subclinical Atherosclerosis - The Chicago Healthy Aging Study (CHAS)
Background: Previous findings on the association of depressive symptoms and subclinical cardiovascular disease (CVD) have been inconsistent. This study aimed to (1) examine the cross-sectional association between depressive symptoms (DS) and subclinical atherosclerosis in older age; and (2) determine whether presence of DS at older age relates to the long-term low-order association of favorable CVD risk factor profile (low-risk) at younger age with subclinical atherosclerosis in older age.
Methods: CHAS participants (n=1,395) were examined in 1967-1973 (baseline) and 2007-2009 (follow-up). Baseline low-risk was defined as: (1) blood pressure ≤120/≤80 mmHg and no reported use of antihypertensive medication, (2) serum cholesterol <200 mg/dL and no reported use of lipid-lowering medication, (3) BMI < 25.0 kg/m2, (4) no diabetes, and (5) no smoking; not low-risk included all others. DS (≥16 on the Center for Epidemiologic Studies Depression Scale [CES-D]) and presence of coronary artery calcification (CAC) >0 (determined by computed tomography) were assessed at follow-up.
Results: Among 1,130 CHAS participants with complete data (mean follow-up age=71.1), 6.9% met criteria for DS. Individuals with DS reported lower sleep quality (p<0.0001) and were more likely to be African American (p<0.0001). At older age, DS were not associated with CAC>0 after multivariate adjustment (p=0.38). Prevalence of DS did not vary significantly between baseline low-risk and not low-risk participants (5.8% and 7.2%, p=0.45). Regardless of late-life depressive symptom status, presence of CAC (indicated by CAC scores > 0) was less likely among low-risk persons (p=0.21) (Table 1). Results were consistent across different CAC score cut-points (data not shown).
Conclusion: Depressive symptoms in older age were not associated with subclinical atherosclerosis or CVD risk status. Low CVD risk status in early-middle age was associated with lower CAC prevalence in older age among persons both with and without depressive symptoms.
- © 2013 by American Heart Association, Inc.