Abstract P107: Restless Legs Syndrome and Self-reported Hypertension in a Large Cohort of Mexican Women
Background: Restless legs syndrome (RLS) is a common movement disorder that affects quality of life and is often unrecognized. RLS has been proposed as marker for increased cardiovascular risk but few studies have evaluated this disorder outside the developed world.
Methods and Results: We evaluated the cross-sectional relation of RLS and self-reported hypertension among 60,088 Mexican women in the ESMaestras cohort, a prospective study of Mexican female teachers, which started in 2006-2008. In 2011, standardized questions addressing the four minimal diagnostic criteria of the International Restless Legs Study Group were included in the follow-up questionnaire. Participants were asked: “Do you have unpleasant leg sensations (like crawling, loss of sensation, or pain) combined with restlessness and an urge to move your legs?”, “Do these symptoms occur only at rest?”, “Does moving improve these symptoms?”, and “Are these symptoms worse in the evening or at night compared with the morning?” Women who answered yes to all the four questions were defined as having RLS. Information on hypertension was obtained from questionnaires. Only responses from 2011, the same year as the questions regarding RLS, were used in this cross-sectional analysis. Individuals who reported hypertension in the prior questionnaires were excluded. Among women with a mean age of 43.8 years (SD ±7.4), the prevalence of RLS was 14.9% (8,971 cases). The age-adjusted odds ratio for hypertension comparing participants with RLS to those without RLS was 1.40 (95% confidence interval 1.32-1.48). After further adjustment for smoking, body mass index, physical activity, oral contraceptive use, and menopause, women with RLS had 1.35 higher odds of hypertension as compared to women with no RLS (95% confidence interval 1.24-1.48). The adjusted odds ratio for women who reported RLS symptoms up to 3 times a month and at least once a week were 1.30 (95% confidence interval 1.15-1.46) and 1.40 (95% confidence interval 1.25-1.55), respectively, compared with those without symptoms (p-trend =0.29).
Conclusion: Women suffering RLS have a higher prevalence of hypertension. This is the first large-scale evaluation of RLS, a disabling and cardiovascular risk-augmenting condition, in Mexico.
- © 2013 by American Heart Association, Inc.