Abstract P082: The Association Between Traditional Cardiovascular Disease Risk Factors and Small Vessel Lower Extremity Arterial Disease In a Healthy Community-dwelling Population: Rancho Bernardo Study
Background: A prior report suggested that small vessel lower extremity arterial disease (svLEAD) was pathophysiologically and epidemiologically distinct from large vessel LEAD (lvLEAD). In a healthy community-dwelling older Caucasian population, we investigated whether traditional CVD risk factors independently contributed to svLEAD, as they did to lvLEAD, and whether the combination of these factors was more strongly associated with disease prevalence.
Methods: We evaluated 965 Rancho Bernardo Study participants with complete measures of ankle-brachial index (ABI), toe-brachial index (TBI), and traditional CVD risk factors. SvLEAD was defined by bilateral normal ABI (1.0-1.4) with bilateral TBI < 0.7. Metabolic syndrome (MS), defined according to ATPIII classification, and the General Framingham Risk Score (GFRS) were used to assess the association of svLEAD with these well-defined CVD risk factor clusters. Associations between svLEAD and CVD risk factors, and the risk factor combinations of MS and GFRS were examined using logistic regression.
Results: Eighty participants (8.3%) met svLEAD criteria. Table 1 presents odds ratios (ORs) for associations of svLEAD with traditional CVD risk factors, MS, and GFRS within the study population as well as stratified by sex. While considering all potential CVD risk factors in our full analysis, only relevant predictors are included in Table 1. Age, male sex, LDL-C and pack-years of smoking were positively associated with svLEAD; and heart rate and waist circumference were inversely associated with svLEAD. These associations did not differ by sex.
Conclusion: Associations between svLEAD and pack-years of smoking, male sex, and LDL-C suggest that svLEAD shares similar risk factors with lvLEAD. Lack of svLEAD associations with other CVD risk factors and their combinations as Metabolic Syndrome or General Framingham Risk Score, however, continues to suggest different pathophysiology.
- © 2013 by American Heart Association, Inc.