Abstract P069: The Relationship of Serum Marine-Derived N-3 Fatty Acids and Carotid Intima-Media Thickness among General Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)
Objective Anti-atherosclerotic properties of marine-derived n-3 fatty acids (MDn3FA) remain controversial. We examined the relationship of serum MDn3FA and carotid intima-media thickness (IMT) in general Japanese men.
Methods Study population was 720 Japanese men aged 50 to 79 without any history of cardiovascular diseases, randomly selected from Kusatsu City, Shiga, Japan, during 2006 to 2008. IMT from common to internal carotid arteries was investigated by ultrasound with a standardized method. Serum fatty acids were determined by capillary gas liquid chromatography. Total MDn3FA was determined by the sum of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA). By the multiple linear regression analysis, standardized coefficient of total MDn3FA, EPA and DHA were estimated in relation to IMT (mm) as the dependent variable, adjusting for possible confounders. Means and multivariate-adjusted means of IMT and 95% confidence intervals (95%CI) were also estimated according to the quartiles of MDn3FA, EPA and DHA.
Results In linear regression models, standardized coefficients of MDn3FA, EPA and DHA in relation to IMT were -0.060 (P=0.109), -0.025 (P=0.51) and -0.077 (P=0.039), respectively. In multiple linear regression models including age, body mass index, systolic blood pressure, blood glucose, HDL- and LDL-cholesterol, smoking, and drinking as covariates, the relationships were similar but not significant. Means and multivariable-adjusted means of IMT were also tended to decrease from the 1st quartile to the 4th quartile of MDn-3FA and DHA, although P for trend was not statistically significant. Any tendency was not observed for EPA. Multivariable-adjusted mean IMT (95%CI) of 1st quartile and 4th quartile were 0.868 (0.843-0.892) and 0.857 (0.833-0.881) for MDn-3FA, 0.879 (0.855-0.903) and 0.858 (0.834-0.882) for EPA, 0.862 (0.838-0.887) and 0.862 (0.838-0.886) for DHA, respectively.
Conclusion Marine-derived n-3 fatty acids, especially DHA, were inversely and non-significantly related to carotid IMT in Japanese men. The anti-atherosclerotic effect of marine-derived n-3 fatty acids should be investigated further.
- © 2013 by American Heart Association, Inc.