Abstract P063: High-density Lipoprotein Particle Concentration is Independently Associated with Carotid Intima-media Thickness in Japanese Men
Background Several lines of evidence suggest that HDL particle (HDL-P) concentration may convey more information regarding the pathogenesis of atherosclerosis in comparison to HDL-cholesterol (HDL-C). However, independent associations between HDL-P and atherosclerosis, as well as cardiovascular incidents, were demonstrated in a limited number of studies and only in Western populations.
Hypothesis We tested the hypothesis that total HDL-P is associated with carotid intima-media thickness (cIMT) independent of potential confounders, including HDL-C and LDL-particle (LDL-P) concentration, among Japanese men.
Methods We cross-sectionally examined a community-based sample of 870 Japanese men aged 40-79 years, in 2006-2008, free of known cardiovascular disease and not on lipid-lowering medication. Lipoprotein profile was assessed by nuclear magnetic resonance spectroscopy. cIMT was measured with ultrasound. Linear regression analyses were used to assess the difference in cIMT per 1 standard deviation (SD) increase in HDL-P and HDL-C, both separately and jointly, with adjustments for age, smoking and hypertension (base model). Adjustments were also made for LDL-cholesterol (LDL-C), HDL size, LDL-P, log-transformed triglycerides (lnTG), and body mass index (BMI) in subsequent models.
Results Both HDL-P (mean ± SD: 34.2 ± 6.7μmol/l) and HDL-C (59.3 ± 17.4mg/dl) were inversely and independently associated with cIMT in separate regression models (p<0.01). However, when adjusted for each other, HDL-C was no longer significantly associated, whereas HDL-P remained significantly associated with cIMT (Table). Even after adjustments for LDL-P, LDL-C, lnTG, and BMI, HDL-P was associated with cIMT (p<0.01).
Conclusions HDL-P remained significantly associated with cIMT after adjustments for potential confounders, both in separate and joint models with HDL-C, among Japanese men. HDL-P may be a potential evaluator for cardiovascular risk as assessed by cIMT.
- © 2013 by American Heart Association, Inc.