Abstract P052: Circulating Fatty Acid Patterns and Incidence of Type 2 Diabetes Mellitus: The Cardiovascular Health Study
Background: Circulating fatty acids (FA) reflect complex interrplay of diet and metabolism. Applying principal component analysis to 39 plasma phospholipid FA in Cardiovascular Health Study (CHS), we previously derived three FA patterns characterized by high levels of trans FA (TFA), de novo lipogenesis FA (DNL), and long-chain monounsaturated FA and dairy FA (LCMUFA-dairy), accounting 43% of total variability of the 39 FA. The TFA pattern was found to be related to higher incidence of CVD. No studies have related these FA patterns to incidence of type 2 diabetes mellitus (DM).
Methods: We evaluated 3,144 adults (age =75.1±5.3 y) free of DM at baseline (1992) in CHS, in whom the plasma phospholipid FA were assessed. Incident DM from 1992 to 2007 was defined as medication use, fasting glucose>126 mg/dL, or 2-hour post-load glucose>200 mg/dL. We examined prospective associations of the TFA, DNL, and LCMUFA-dairy patterns with incident DM using multivariate Cox proportional hazards. We also assessed potential mediation by baseline risk factors including adiposity, lipids and blood pressure.
Results: During 29,010 person-years, 361 DM events occurred. The TFA and LCMUFA-dairy patterns were each associated with lower DM risk (HR for quintiles 5 vs 1=0.46 [95% CI=0.29-0.72] and 0.45 [0.28-0.71], respectively) (p trend<0.001 each) (Figure). These associations were partly attenuated by adjustment for potential mediators: HR=0.67 (0.42-1.07) and 0.61 (0.38-0.99) (p trend=0.02 and 0.13), respectively. The DNL pattern was not significantly associated with incident DM (HR=1.33 [0.82-2.16]; p trend=0.34).
Conclusions: The circulating FA patterns characterized by high TFA levels and by high LCMUFA and dairy FA levels were linked to lower DM incidence. These findings are in line with some prior studies relating TFA and dairy FA to DM, but not with our prior finding on TFA pattern and CVD. Potentially informative beyond work on individual FA, our work suggests need for research to elucidate biological roles of the observed FA patterns
- © 2013 by American Heart Association, Inc.