Abstract P041: Glucose Rise on Statins in Older Age: Adaptive Protection Against Fatigue?
Background: We previously showed that statins increase a composite fatigue measure; and that statins increase glucose preferentially in those over age 55 - increasingly with each decade, particularly in presence of risk factors for impaired bioenergetics. We speculated that glucose elevations may be adaptive defenses of cell energy, and assessed whether greater glucose elevations on statins, in those over age 55, were linked to lesser risk of fatigue on statins.
Method: 1016 participants age >20 were randomized equally to simvastatin 20mg, pravastatin 40mg or placebo. Baseline and 6mo (on-treatment) glucose (mg/dL) were assessed and glucose change calculated. The fatigue change measure, summed self-rated changes in exertional fatigue and in energy (aligning signs). Regression assessed the relation of glucose-change to fatigue change (using the continuous glucose measure as the dependent variable), adjusted for baseline glucose, stratified by treatment.
Results: As age advanced, glucose change over 6 months showed increasing inverse associations with fatigue change, on statins and particularly simvastatin (Table). Qualitatively similar tendencies on placebo did not reach significance.
Discussion: Greater glucose rise in older age, particularly on statins, was linked to lesser fatigue and exertional-fatigue symptoms, with potential implications for function. We speculate that glucose rise e.g. in older age/ on statins may represent a physiological adaptation to protect against bioenergetic insufficiency.
- © 2013 by American Heart Association, Inc.