Abstract P024: Maternal Genotype Accounts for Part of the Relationship Between Maternal Size During Pregnancy and Offspring Metabolic Profile in Adulthood
Background: Maternal pre-pregnancy body-mass index (BMI) and gestational weight gain (GWG) are associated with cardiometabolic risk (CMR) in adult offspring. However, whether common maternal genetic variation accounts for the association of pre-pregnancy BMI and GWG with markers of offspring CMR at age 32 is unknown.
Methods and Results: Using archival and follow-up data from 1249 mother-offspring pairs and 1384 single-nucleotide polymorphisms (SNPs) in 170 candidate genes related to cardiometabolic traits from the Jerusalem Perinatal Study (JPS), we created maternal genetic risk scores using the subset of SNPs that were most predictive of exposure and outcome, and fit linear regression models both with and without genetic terms to examine the association of maternal size before pregnancy and weight gain during pregnancy with offspring CMR, measured by offspring BMI, waist circumference, glucose, insulin, blood pressure, and fasting lipid levels. Offspring with low and high birthweight were oversampled, as were overweight and obese mothers, and analyses used inverse probability weighting to account for this sampling scheme.
In GWG models unadjusted for genetic score compared to adjusted models, the coefficient for the BMI term decreased by 41% (95% CI -81%, -11%) from 0.184 to 0.109 and the coefficient for the WC term decreased by 63% (95% CI -318%, -11%) from 0.259 to 0.096. Significant changes in coefficients were neither seen for the other CMR traits tested nor in corresponding pre-pregnancy BMI models.
Conclusions: In this analysis, maternal genotype accounts for part of the association between gestational weight gain and body size in adult offspring. A similar genetic contribution was not seen in the association between pregravid size and offspring CMR.
- © 2013 by American Heart Association, Inc.