Abstract P017: Which Measures of Adiposity Predict Subsequent Left Ventricular Geometry? Evidence from The Bogalusa Heart Study
Left ventricular (LV) hypertrophy increases risk of future cardiovascular events. The relationship between obesity in young adulthood and later LV geometry is unknown. We examined the association between long-term changes in measures of adiposity and subsequent LV hypertrophy among 1,073 adults from the Bogalusa Heart Study. Data on measures of adiposity included body mass index (BMI), waist circumference, waist/hip ratio, waist/height ratio, abdominal height, and body fat (%) from skin folds. Standard indices of LV geometry were assessed by M-mode echocardiography. LV geometry was classified into normal, concentric remodeling, eccentric hypertrophy, and concentric hypertrophy by integrating relative wall thickness and LV mass index. The mean age of population was 38 years when LV geometry was measured. There were 796 adults with normal LV geometry, 126 with concentric remodeling, 99 with eccentric hypertrophy, and 54 with concentric hypertrophy. Increases were seen in several measures: BMI increased by 4.4 kg/m2 over 18 years, waist circumference by 9.8 cm over 15.3 years, waist/hip ratio by 0.03 over 10.2 years, waist/height ratio by 0.06 over 18 years, abdominal height by 0.95 cm over 7.3 years, body fat (%) by 13.5% over 18 years. In multivariate logistic regression models, participants with a one standard deviation increase in BMI, waist circumference, waist/height ratio, and body fat had 2.28 (95%CI: 1.67 to 3.11), 1.64 (95%CI: 1.22 to 2.18), 1.67 (95%CI: 1.28 to 2.19), and 1.84 (95%CI: 1.39 to 2.45) times the risk of having eccentric LV hypertrophy on echocardiography, respectively, after adjustment for age, sex, race, hypertension status, physical activity levels, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, fasting blood glucose, smoking and daily alcohol drinking. There was no significant association with concentric hypertrophy. Our findings suggest that increases in BMI, waist circumference, waist/height ratio, and body fat % were strong predictors of eccentric LV hypertrophy in middle age.
- © 2013 by American Heart Association, Inc.