Abstract MP17: Testosterone Change Relates to Lipid Change on Statins
Background: Cholesterol is a precursor for steroid hormones. We sought to assess whether as well as how lipid change in men on statins relates to testosterone change.
Methods: 694 men over age 20 without DM or CVD were randomized equally to simvastatin 20mg, pravastatin 40mg or placebo for 6 months in a double blind RCT. For each arm, final (6mo) testosterone (ng/mL) was compared to baseline testosterone (paired t-tests). Testosterone-change-on-statin was compared to testosterone-change-on-placebo (unpaired t-tests). Regression examined how change in testosterone related to change in lipid elements (mg/dL), stratified by statin.
Results: Baseline testosterone was comparable across arms (~4.4ng/mL). Testosterone on-treatment was significantly lower than at baseline (paired t-tests) on statins but not on placebo (Table). Testosterone drop was significantly greater in the statin than the placebo group (unpaired t-test, Table). Change in testosterone on simvastatin (but not pravastatin) related significantly to change in LDL (P<0.001). In contrast, change in testosterone on pravastatin (but not simvastatin) related significantly to change in HDL (P=0.005).
Discussion: Statins produced modest but significant average declines in testosterone in men. Change in testosterone on statins related significantly to change in lipids, differently for simvastatin and pravastatin.
- © 2013 by American Heart Association, Inc.