Abstract MP10: Long-Term Favorable Cardiovascular Risk Profiles and Cardiovascular Disease
Background. Often, studies on risk factors (RFs) and cardiovascular disease (CVD) use a single measurement of exposure without taking into account changes in RFs profiles over time. Cumulative exposure over a longer period gives most likely a better reflection of lifetime risk. We assessed the impact of 10-year exposure to favorable levels of all 5 major CVD RFs (low-risk) and other RF combinations on CVD morbidity and mortality.
Method. RFs were measured at baseline (1987-1991) and re-measured at 6 and 11 years of follow-up in 5678 adults aged 20-59 years. Based on these 3 measurements of blood pressure, cholesterol, body mass index, diabetes and smoking, participants were classified into 5 long-term RFs categories, including low risk (for definition, see footnote Table 1). Morbidity data, vital status and causes of death were obtained through linkage with national registries. Missing data were imputed (Multivariate Imputation by Chained Equations), and age- and sex-adjusted hazard ratios and 95% confidence intervals (95%CIs) were estimated using Cox proportional hazards models.
Results. Looking at long-term RF profiles, 8% of participants were low risk, 12% unfavorable, 15% had 1 RF, 55% varied between RF groups, and 10% had ≥ 2 RFs. During an average of 7.2 years follow-up, 283 CVD events occurred. The CVD event rate was higher with greater number of long-term RFs (Table 1). Adjusted CVD hazard ratio for having a long-term low RF profile was 0.16 (95%CI: 0.06-0.45) compared to having long-term ≥ 2 RFs. Similar patterns were observed for men and women, and for different socio-economic classes.
Conclusion. Adults with long-term favorable levels of all 5 major risk factors had a more than 6 times lower risk of CVD than those with 2 risk factors or more.
- © 2013 by American Heart Association, Inc.