Abstract MP09: Associations between Serum Albumin Levels and Risks for All-cause Mortality and Cause-specific Mortality in an Elderly Japanese Community-dwelling Population
Background: Low serum albumin (SA) levels are associated with increased risks for all-cause mortality and cause-specific mortality in middle-aged people. However, whether there is an association between SA levels and cause-specific mortality in elderly people is still controversial.
Objective: To examine associations between SA levels and risks for all-cause mortality and cause-specific mortality in an elderly community-dwelling population.
Methods: A total of 8803 men and women aged 65 years or older (mean age, 71 years) who had no history of stroke or myocardial infarction were followed up prospectively for 5.7 years. Death and date of death were verified by reviewing the basic resident register. Cause of death was determined by reviewing the death certificate. Participants were classified into four groups according to SA levels (g/L): G1, less than 40 (n = 1095); G2, 41-42 (n = 2011); G3, 43-44 (n = 2634); and G4, 45 or over (n = 3063, a reference group). Multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality from all causes, cancer, cardiovascular disease (CVD), and non-cancer, non-CVD in each group of SA levels were estimated with adjustments for age, sex, body mass index, systolic blood pressure levels, total cholesterol levels, HDL cholesterol levels, HbA1c levels, current smoking, regular drinking and regular exercise using Cox’s regression.
Results: During the follow-up, 605 deaths occurred (228 cancer deaths, 142 CVD deaths and 181 non-cancer, non-CVD deaths). Persons in G1 had significantly higher risk for mortality from all causes, cancer, CVD and non-cancer, non-CVD than did those in G4. For mortality from all causes and CVD, a significant higher risk was also found in G2. (See table)
Conclusion: Low SA levels, even when within the clinical normal range, are associated with increased risks for mortality from all causes and CVD in elderly people.
- © 2013 by American Heart Association, Inc.