Abstract 034: Circulating Biomarkers of n-3 and n-6 Polyunsaturated Fatty Acid and Incidence of CVD in the Multi-Ethnic Study of Atherosclerosis (MESA)
Background: Dietary guidelines support intakes of fish and vegetable oils due to potential cardiovascular benefits of polyunsaturated fatty acid (PUFA) intake. However, new evidence has raised controversy about benefits of PUFA, and most prior studies have relied on self-reported dietary assessment in relatively homogeneous populations.
Aims: To test the hypothesis that circulating biomarkers of fish and plant -plasma phospholipid n-3 (ALA [18:3], EPA [20:5], DPA [22:5], DHA [22:6]) and n-6 (LA [18:2], AA [20:4]) PUFA would be inversely associated with incident CVD and CHD in a multiethnic US population.
Methods: We evaluated 2,837 U.S. adults 45-84 y at baseline (2000-2002) from four race-ethnic groups (Caucasians, Hispanics, African and Chinese Americans), in whom circulating PUFA levels were measured using validated gas-chromatography. Incident CVD (MI, resuscitated cardiac arrest, definite and probable angina, stroke, CVD death; 189 cases) and CHD (MI, resuscitated cardiac arrest, CHD death; 141 cases) were adjudicated through 2010 during cohort examinations and follow-up calls. Multivariable-adjusted Cox proportional hazards models estimated hazard ratios for CVD and CHD. We also evaluated the influence of potential mediators including blood lipids and inflammatory markers.
Results: After adjustment for demographic, lifestyle and dietary factors, fish-derived n-3 PUFA levels were associated with lower CVD and CHD risk (see Table). Associations were similar after adjustment for lipids and inflammatory markers. No associations were observed between plant-derived n-3 or n-6 PUFA and CVD or CHD. All associations were similar across racial-ethnic groups, except those of DPA, which were stronger among Chinese and Caucasians (Pinteraction=0.02 for total CVD and CHD).
Conclusion: Plasma phospholipid EPA, DPA and DHA were inversely associated with CVD and CHD incidence in a multi-ethnic cohort. These findings support increased consumption of n-3 PUFA from fish to prevent CVD development.
- © 2013 by American Heart Association, Inc.