Letter by Nanthakumar and Waxman Regarding Article, “Sudden Cardiac Arrest and Death Following Application of Shocks From a TASER Electronic Control Device” ================================================================================================================================================================ * Kumaraswamy Nanthakumar * Menashe Waxman ## To the Editor: We read with interest the important article by Zipes. Zipes has reported 8 cases of ventricular fibrillation (VF) after TASER shocks.1 His findings indeed validate animal reports that have shown that TASER discharges can stimulate the myocardium. His findings are predicted by our early work on the vector, duration of the TASER discharge, and the associated sympathetic stress that are related to the onset of myocardial capture, the degree of myocardial capture, and the propensity to ventricular fibrillation.2 Two important facts that Dr Zipes produced in his article need attention. Zipes has demonstrated 1 episode of asystole following TASER discharge and another recording in which it was was difficult to differentiate fine VF from asystole.1 Although there are many mechanisms, including respiratory effects, whereby TASER shocks could lead to asystole, Zipes’ report highlights the need to consider how TASER-induced ventricular tachycardia/VF might appear as asystole. The 2 mechanisms to consider are (a) transition of VF to asystole secondary to hyperkalemia and (b) continuation of VF in a deeper layer of heart muscle with electric silence in the epicardial regions.3 Among Zipes’ tracings that revealed asystole, recordings were performed long after the initial discharge. Cases 5 and 8 were indeed performed after a prolonged period, 13 minutes and 30 minutes after the discharge, respectively. Swerdlow et al4 described that the heart rhythm of ≈90% of 56 cases of death associated with TASER were severe bradyarrythmias or asystole. Transition from VF to asystole after a long time from discharge to initial recording could be due to potassium accumulation in the myocardium leading to termination of the VF. In addition, after long durations of VF, the epicardium may not reveal any activity, and, thus, the surface ECG does not reflect the activity within the myocardium. Thus, recordings made long after VF onset with surface leads, in our opinion, may appear as asytole, and this may explain the discrepancy in the literature where long-duration VF masquerades as asystole.4 Zipes’ work suggests that it is possible that TASER causes ventricular tachycardia/VF in some subjects, and the collapse ECG shows VF, and, in other cases such as cases 5 and 8, it may be possible that VF transforms to asystole as time passes by. A second feature of Zipes’ study highlights is the lack of information on the temporal sequence of myocardial capture in relation to TASER shock. This temporality is important, because it is not known how long a discharge is needed before myocardial stimulation will occur, and this issue has practical implications. In the series of patients by Zipes even those with just 1 TASER shock were found to be in VF. This brings to light the fact that we need to determine exactly when during the discharge does one induce rapid ventricular capture and VF, and how consistent or erratic does this capture have to be for deleterious consequences to evolve. This needs to be carefully studied to give practical guidance to law enforcement officers, because it may determine the safe duration of TASER discharge to reduce unintended consequences such as VF. This would precede the safety step of having an automated external defibrillator for monitoring after a collapse incidence. It is important to recognize the valuable contribution made by Dr Zipes in this area, because he sheds light on a complicated issue. **Kumaraswamy Nanthakumar, MD**
**Menashe Waxman, MD**
*Division of Cardiology*
*University Health Network*
*Toronto General Hospital*
*Toronto, Ontario, Canada* ## Disclosures Dr Waxman has served as an expert witness in litigation relevant to the topic of the article about which this letter is written. * © 2013 American Heart Association, Inc. ## References 1. 1.Zipes DP. Sudden cardiac arrest and death following application of shocks from a TASER electronic control device. Circulation. 2012;125:2417–2422. [Abstract/FREE Full Text](http://circ.ahajournals.org/lookup/ijlink?linkType=ABST&journalCode=circulationaha&resid=125/20/2417&atom=%2Fcirculationaha%2F127%2F1%2Fe257.atom) 2. 2.Nanthakumar K, Billingsley IM, Masse S, Dorian P, Cameron D, Chauhan VS, Downar E, Sevaptsidis E. Cardiac electrophysiological consequences of neuromuscular incapacitating device discharges. J Am Coll Cardiol. 2006;48:798–804. [CrossRef](http://circ.ahajournals.org/lookup/external-ref?access_num=10.1016/j.jacc.2006.02.076&link_type=DOI) [PubMed](http://circ.ahajournals.org/lookup/external-ref?access_num=16904552&link_type=MED&atom=%2Fcirculationaha%2F127%2F1%2Fe257.atom) [Web of Science](http://circ.ahajournals.org/lookup/external-ref?access_num=000239771100019&link_type=ISI) 3. 3.Kong W, Ideker RE, Fast VG. Transmural optical measurements of Vm dynamics during long-duration ventricular fibrillation in canine hearts. Heart Rhythm. 2009;6:796–802. [CrossRef](http://circ.ahajournals.org/lookup/external-ref?access_num=10.1016/j.hrthm.2009.02.028&link_type=DOI) [PubMed](http://circ.ahajournals.org/lookup/external-ref?access_num=19467507&link_type=MED&atom=%2Fcirculationaha%2F127%2F1%2Fe257.atom) [Web of Science](http://circ.ahajournals.org/lookup/external-ref?access_num=000266658800013&link_type=ISI) 4. 4.Swerdlow CD, Fishbein MC, Chaman L, Lakkireddy DR, Tchou P. Presenting rhythm in sudden deaths temporally proximate to discharge of TASER conducted electrical weapons. Acad Emerg Med. 2009;16:726–739. [CrossRef](http://circ.ahajournals.org/lookup/external-ref?access_num=10.1111/j.1553-2712.2009.00432.x&link_type=DOI) [PubMed](http://circ.ahajournals.org/lookup/external-ref?access_num=19473120&link_type=MED&atom=%2Fcirculationaha%2F127%2F1%2Fe257.atom)