Abstract 9727: High Serum Level of Tenascin-c is Related to Coronary Plaque Rupture in Patients With Acute Coronary Syndrome
Purpose: Tenascin-C is a multifunctional protein and increases the expression of matrix metalloproteinases which lead to atherosclerotic plaque instability. Destabilization of coronary plaque is relevant to plaque rupture resulting in acute coronary syndrome (ACS). We hypothesized that serum tenascin-C level is higher in patients with ACS than in those with stable effort angina (SAP), and high serum level of tenascin-C is associated with plaque rupture in patients with ACS.
Methods: Consecutive 52 ACS patients who underwent emergent percutaneous coronary intervention (PCI) and consecutive 66 patients with SAP who underwent elective PCI were enrolled in this study. Blood samples were obtained from ascending aorta just prior to the PCI procedures, and circulating serum level of tenascin-C was measured using there samples. After coronary guidewire crossing, intravascular ultrasound (IVUS) was performed for assessment of plaque characterization including coronary plaque rupture. ACS patients were assigned to two groups according to whether there was ruptured plaque (ACS-ruptured group) or not (ACS-non-ruptured group).
Results: There were 23 patients in ACS-ruptured group and 29 patients in ACS-non-ruptured group. Clinical characteristics and IVUS findings of the lesion did not differ among SAP, ACS-ruptured and ACS-non-ruptured groups. Serum tenascin-C level in ACS-ruptured group was significantly higher than SAP patients, whereas there was no significant difference between ACS-non-ruptured group and SAP group. Importantly, in ACS-ruptured group, serum tenascin-C level was significantly higher than ACS non-ruptured group.
Conclusions: Our data demonstrate that serum tenascin-C level is related to the pathological condition of ACS, especially the ruptured plaque estimated by IVUS observation. These results suggest that serum tenascin-C level is a novel biomarker for coronary plaque rupture in patients with ACS.
- © 2012 by American Heart Association, Inc.