Abstract 9351: Left Ventricular Torsion is Preload Dependent. A Study in Healty Volunteers After Blood Donation

Abstract

Introduction: Left ventricular (LV) rotation plays an important role in LV contraction and relaxation.

Hypothesis:Aim of this study is to investigate preload effect on LV torsion in normal volunteers of blood donation.

Methods and Results: LV end-diastolic volume, LV apical and basal rotation, peak systolic LV Torsion were measured by speckle-tracking echocardiography in normal volunteers (n=26) before and after 450ml blood donation.Blood donation led to a significant decrease in end-diastolic LV internal diameter (48.7 + 0.4 versus 46.4+0.4 mm; P<0.001) and cardiac output (6.2 + 1.0 versus 5.1+ 0.7 L/min; P<0.001). There was a significant decrease in the magnitude of peak systolic apical rotation (4.4 +1.9° versus 2.9 + 1.5°; P<0.001) but no change in basal rotation (2.6 +1.4° versus 2.7+ 1.6°; P=0.81). Peak systolic LV Torsion decreased after blood donation (6.9 +1.9 ° versus 5.7+2.1°; P=0.028).

Conclusions: LV apical and peak systolic LV torsion are preload dependent. Preload changes should be considered when interpreting LV torsion