Abstract 9003: Evolution of the Arterial Structure and Function from Infancy to Adolescence is related to Anthropometric and Blood Pressure Changes
Objective: To develop a normative dataset and to study the relationship between arterial structure, different anthropometric measures, blood pressure and arterial function during healthy childhood using very-high resolution ultrasound (25-55 MHz).
Methods and Results: In 135 healthy children between 0 and 18 years we assessed the structure of the carotid arteries, larger peripheral arteries, aorta and left ventricle with ultrasound. Arterial stiffness was assessed by pulse wave velocity (PWV) and endothelial function by brachial flow-mediated dilatation (FMD). Reference curves adjusted for age and body surface area of arterial lumen diameters (LD), intima-media (IMT) and adventitia (AT) thickness were developed. Arterial walls thicken during childhood predominantly due to a progressive increase in IMT. There were significant associations between LD (R2 range: 0.20-0.88 for different arteries; p<0.001), IMT (R2 range: 0.47-0.85; p<0.001), left ventricular mass (LV mass; R2 = 0.90; p<0.001) and AT (R2 range: 0.15-0.22; p<0.001) with gender, age, body surface and systolic blood pressure. Arterial wall stress was associated with LD (R2 range 0.52-0.83; p<0.001) and IMT (R2 range 0.53-0.88; p<0.001). Limited relations were found between arterial wall layer thickness, stiffness and endothelial function.
Conclusion: In healthy children the evolution of the arterial structure is mainly related to anthropometrics and blood pressure.
- © 2012 by American Heart Association, Inc.