Abstract 8975: A Study of Left Ventricular Septal Wall 2D Radial and Circumferential Strain in Dyssynchrony
Background: This study used 2D speckle tracking to analyze the effects of simulated synchrony and dyssynchrony on left ventricular (LV) septal strain.
Methods: The atria were removed from 8 pig hearts and balloons were sewn into both ventricles at the annulus of the mitral and tricuspid valves. Each ventricular balloon was attached to a separate pulsatile pump. Each heart was imaged in a water bath at 4 different stroke volumes (SV) (30-60) at a pump rate of 50bpm. End diastolic volume (EDV) was increased incrementally with each increase in SV by injecting water into the closed system. For each SV, images were obtained in states of ventricular synchrony and dyssynchrony. 2D echo images in the short axis view were obtained using a GE Vivid 7 echocardiography system and analyzed using EchoPac PC 2D Q analysis of strain.
Results: Statistically significant differences in septal strain were observed in states of synchrony vs. dyssynchrony. In dyssynchrony, radial septal strain (RS) showed a significant decrease compared to synchronous at each stroke volume (RS: SV 30, p = 0.051; SV 40, p = 0.016; SV 50, p = 0.043; SV 60, p = 0.029). Dyssynchronous circumferential strain (CS) showed a significant increase compared to synchronous at each stroke volume (CS: SV 30, p = 0.006; SV 40, p = 0.013; SV 50, p = 0.1739; SV 60, p = 0.02).
Conclusions: There are significant differences in the radial and circumferential strain of segments of the left ventricular wall during states of dyssynchrony.
- © 2012 by American Heart Association, Inc.