Abstract 206: Intravenous Lipidic Oxygen Microparticles Improve Arterial Oxygen Content and Cerebral Oxygen Delivery During CCC-Only CPR
Background: Although the effectiveness of CCC-only CPR is well-established, the benefits of adjuncts to further improve systemic oxygen delivery merit study. Oxygen gas can be encapsulated within injectable microparticles, or lipidic oxygen microparticles (LOMs), which transfer oxygen rapidly to the bloodstream within seconds of intravenous injection. The purpose of this study was to determine whether LOMs increase arterial oxyhemoglobin concentration, oxygen delivery and affect ROSC in a porcine model of experimentally-induced VF employing CCC-only CPR.
Methods: Yorkshire swine (30 kg) were sedated with Ketamine and Xylazine for tracheal intubation and placement of femoral venous and arterial catheters. VF was induced and animals were immediately extubated and treated as shown in Fig 1A. CPR depth, rate, and leaning was guided in all animals with real time feedback from the monitor/defibrillator. Animals with shock-refractory VF were randomized to treatment with standard ACLS therapy with (n=5) or without (n=3) intravenous LOMs (Fig 1A).
Results: Relative to controls, animals treated with LOMs in addition to standard ACLS therapy exhibited a significantly increased arterial oxyhemoglobin saturation during LOM administration (P<0.0001, 2 way ANOVA, Fig 1B), a higher cerebral NIRS during LOM administration (P<0.0001, linear regression, Fig 1C), a higher diastolic blood pressure during LOM administration (P<0.0001, linear regression, Fig 1D), and a trend towards increased incidence of ROSC (P=0.36, Fig 1E). CPR quality (depth and rate) was similar between groups (P=1.00).
Conclusion: LOMs may increase arterial oxygen content, cerebral oxygen delivery during CCC-only CPR, and may be a useful adjunctive therapy in non intubated patients with out-of-hospital cardiac arrest.
- © 2012 by American Heart Association, Inc.