Abstract 19702: Bending Flexibility of Stents: Comparison among Four DES Platforms with Different Design and Materials Deployed in in-vivo Simulated Cyclically-Bending Coronary Artery Model
Objective: Deployment of coronary stents in bending coronary artery often provokes changes in cyclic bending angles during cardiac contraction and relaxation. We investigated cyclic bending flexibility of four drug eluting stents consisted from different design and materials, using a novel methodology using in-vivo simulated cyclically-bending and mechanically-matched coronary artery model.
Methods: Based on angiographic data of bending angles of proximal right coronary artery (RCA) in end-systole and end-diastole of 63 patients, the angle data matched to type-B according to ACC/AHA guideline were used to fabricate a RCA model. Because the average angles in end-systole and end-diastole were 105° and 125°, stents were deployed in the coronary artery models which are cyclically bended between 105° and 125°. Mechanical stiffness of the coronary artery model was adjusted to that of referenced human coronary artery. Promus Element PtCr stents (3×20mm), Resolute Integrity MP35N CoCr stents (3×18mm), Xience Prime L605 CoCr stents (3×18mm), Cypher SUS 316L stents (3×18mm) were deployed in the transparent elastic bending coronary artery mode at each nominal balloon inflation pressure (n=6 each). Bending angles of stents were analyzed using digital microscope.
Results: Bending flexibility was clearly differentiated among four DES platforms as shown in the figure. These data indicated that Promus Element PtCr stents was most flexible among the four stents in response to cyclic deformation of the coronary artery model. There were significant differences in the bending angles both in end-systole and end-diastole as well as in the traveling angles.
Conclusion: Cyclic bending flexibility of four DES consisted from different design and materials was quantitatively revealed using a novel methodology.
- © 2012 by American Heart Association, Inc.