Abstract 19648: Exposure to Ionized Medical Radiation after Heart Transplant is Associated with Higher Risk of Malignancies
Objective Evidence on the increase cancer risk due to medical radiation is mounting. Heart transplant (OHT) patients are at high risk for cancer due to immunosuppression medications. In this study we shout to determine the correlation between the cumulative ionized medical radiations after OHT to the development of cancer.
Methods: Adult Patients transplanted between 1999-2010 without history of cancer in a large medical center were included in this analysis. Medical tests that expose the patients to radiation (i.e X-ray, Computer Tomography (CT), nuclear test and cardiac catheterization) were collected from the hospital database, and the amount of radiation was calculated based on a look up tables specified for our institution. The prevalence of cancer was recorded from electronical medical records.
Results: 891 patients were enrolled to the study. Age 52.3±13.0 years old, 677 (75.9%) were male. The mean follow up time post OHT was 6.9±3.3 years and 76 (8.5%) patients developed de-novo malignancy. Prostate cancer was the most common 20%, followed by lung 17% and hematologic malignancies 13%. The mean time for development of malignancy was 5.2±3.4 years. Patients that developed cancer were exposed to significantly more ionizing radiation 68.0 ± 65.9 mSv vs 54.4 ± 45.9 mSV (p=0.026) respectively. Cumulative radiation exposure was the only variable associated with the development of de-novo cancer in a multivariable regression model (for every increase of 10mSv the chance of cancer increase by 5.1% P=0.046). Patients in the higher tertile of radiation exposure had 40% more chance to develop cancer (Figure).
Conclusion High frequency of early post OHT malignancy was reported. There was a strong association between the amounts of medical ionizing radiation to the frequency of post OHT malignancy. This is the first study to report actual cancer percentage in relate to radiation exposure. Minimized the amount of radiation post OHT may reduce the frequency of cancer.
- © 2012 by American Heart Association, Inc.