Abstract 18780: The Impact of Anemia Severity on Angiographic and Clinical Outcomes following Percutaneous Coronary Intervention with Drug-eluting Stents in Asian Population

Abstract

Background: The significance of anemia in patients (pts) undergoing percutaneous coronary intervention (PCI) remains controversial. The aim of this study was to evaluate the impact of the severity of anemia on the angiographic and clinical outcomes following PCI with drug eluting stent (DES).

Methods: A total of 881 consecutive pts underwent PCI with DESs were enrolled. Anemia was defined using World Health Organization criteria with hematocrit (Hct): mild anemia (female: 29%≤Hct<36%, male:29%≤Hct<39%, A1, n=485), moderate to severe anemia (Hct<29%, A2, n=50), and no anemia (female: Hct≥36%, male: Hct≥39%, A0, n=507). Six-month angiographic and 1 year clinical outcomes were compared among the three groups.

Results: At baseline, the rate of female gender, old age, the incidence of ST elevation myocardial infarction (STEMI), hypertension, diabetes mellitus, chronic renal disease, and congestive heart failure were highest in the Group A2. The incidence of left main and multivessel PCI was highest in the Group A2. At 6 months, the angiographic outcomes were worst in the Group A2. At 12 months, the cumulative incidence of total deaths, any myocardial infarction, and all major adverse cardiac events (MACEs) up to 2 years were highest in the Group A2 (Table). Multivariate analysis showed that anemia was an independent predictor of mortality at 2 years (Adjusted OR 3.78, CI 2.19-6.52, p<0.001).

Conclusions: In conclusion, the severity of anemia on admission in pts undergoing PCI with DESs was associated with higher mortality and MACEs up to 2 years, suggesting special care should be exercised when a pt has moderate to severe anemia on admission.