Abstract 18508: The Association of eNOS Gene Single Nucleotide Polymorphism rs1799983 with High-Sensitivity C-Reactive Protein and Early Recurrence of Atrial Fibrillation after Radiofrequency Catheter Ablation
Background: Previous reports have demonstrated the association between single nucleotide polymorphism (SNP) of the eNOS gene and atrial fibrillation (AF). This study evaluated whether eNOS gene variants are associated with high-sensitivity C-reactive protein (hsCRP) and AF recurrence after radiofrequency catheter ablation (RFCA).
Methods: A total of 500 consecutive patients (56±11 years, 77% male) with paroxysmal (68%) or persistent (32%) AF who underwent RFCA were included. Plasma hsCRP concentration was measured and SNP of the eNOS gene, rs1799983, was genotyped. A 24- to 48-hour Holter ECG recording was performed at 3, 6, and 12 months after the ablation.
Results: When we compared the patients with rs1799983 variant allele (T, n=84) and those without T allele (n=416), rs1799983 variant allele carriers are more likely to have coronary artery disease or stroke (31.0% vs. 17.8%, p=0.004). The early recurrence (ER) of AF (within 3 months) was observed in 31.8%, whereas the clinical recurrence (CR) of AF (after 3 months) occurred in 24.8% of the patients during the median 17 months of follow-up. The patients with ER were more likely to have persistent AF (44.4% vs. 27.1%, p<0.001) and larger left atrium (42.8±6.4 vs. 41.2±6.2 mm, p=0.011) than those without the ER. Although rs1799983 variant was not associated with the CR, carriers of the variant allele had an increased risk of the ER (OR 1.717 for TT+GT vs. GG, 95% CI 1.059-2.785, p=0.028) and experienced recurrence earlier than those without variant allele (11±16 vs. 20±25 days, p=0.016). However, there were no significant differences in hsCRP between variant and non-variant patients (2.32±4.94 vs. 2.06±4.36 mg/L, p=0.618). A multiple logistic regression analysis showed that the rs1799983 variant (OR 1.714, 95% CI 1.045-2.812, p=0.033) and persistent AF (OR 1.905, 95% CI 1.234-2.939, p=0.004) were independent predictors of the ER.
Conclusions: The rs1799983 variant of the eNOS gene was associated with early recurrence after RFCA, but not with hsCRP level. A study that further investigates the relationship between genetic variations of eNOS and post-ablation inflammatory process will be warranted.
- © 2012 by American Heart Association, Inc.