Abstract 18468: Associations Between Clinical Characteristics and NT-proBNP in Heart Failure with Preserved Ejection Fraction: Data from the KaRen Study
Purpose: In heart failure with reduced ejection fraction, N-terminal pro brain natriuretic peptide (NT-proBNP) is useful for diagnosis and prognosis, and is higher with older age, female gender, renal failure and lower in obesity. In heart failure with preserved ejection fraction (HFPEF), NT-proBNP is also useful for diagnosis and prognosis, but clinical correlates are less well established.
Methods: KaRen is a multicenter prospective registry of HFPEF. Inclusion criteria are acute presentation with Framingham symptoms and signs of heart failure together with NT-proBNP >300 ng/L and LVEF >=45%. The association between clinical characteristics and log NT-proBNP was assessed with uni- and multivariate linear regression, with backward step-wise selection based on p < 0.05.
Results: We studied 400 patients, mean (SD) age 77 (9) years, 56% women. The table lists variables independently associated with log NT-proBNP, their baseline values and Beta coefficients.
Conclusions: In HFPEF, NT-proBNP is determined mainly by NYHA class and clinical signs of heart failure. Clinical signs are important predictor of severity of disease. As in reduced ejection fraction, NT-proBNP is inversely associated with BMI and GFR, but unlike in reduced ejection fraction, it is not associated with age or gender.
- © 2012 by American Heart Association, Inc.