Abstract 18408: The Impact of Anemia on 3-year Clinical Outcomes in Patients Undergoing Percutaneous Coronary Itervention Using Drug-eluting Stent: Insights from the CREDO-Kyoto PCI/CABG Registry Cohort-2
OBJECTIVES: We investigated the impact of anemia on outcomes after percutaneous coronary intervention (PCI) using drug-eluting stent (DES).
BACKGROUND: Patients with anemia have a higher risk of adverse outcomes after PCI. However, long-term outcomes of anemia after contemporary PCI using DES have not been fully investigated.
METHODS: We performed a retrospective cohort study of 5336 consecutive patients who underwent first PCI using DES between 2005 and 2007, to assess the impact of anemia on long-term outcomes.
RESULTS: Anemia (hemoglobin <13g/dl for men and 12g/dl for women, respectively) were observed in 33.5% of study patients. Patients with anemia were older and more frequently women and have comorbidities such as diabetes mellitus, hypertension, and chronic kidney disease (p<0.0001). In addition, patients with anemia received more complex PCI using longer and smaller-size stents (p<0.05). Cumulative incidence of all cause death, cardiac death, and sudden cardiac death was higher in patients with anemia compared to those without anemia (16.4% vs. 3.6%; p<0.0001, 7.1% vs. 1.7%; p<0.0001, and 3.0% vs. 0.9%; p<0.0001, respectively). In adjusted analyses, anemia was associated with a significantly increased risk of all cause death (HR, 1.96; 95% CI, 1.49-2.58; p<0.0001), a trend toward high risk of cardiac death (HR, 1.36; 95% CI, 0.90-2.06; p=0.1), and sudden cardiac death (HR, 1.69; 95% CI, 0.90-3.18; p=0.09).
CONCLUSIONS: Anemia is frequent among patients undergoing PCI using DES and significantly associated with disease severity and worse prognosis.
- © 2012 by American Heart Association, Inc.