Abstract 18313: Gender Differences in the Early Mortality of Octogenarian Patients with Acute Myocardial Infarction From a Registry Database in Japan

Abstract

Background: During the previous 2 decades studies have consistently shown that younger women hospitalized with an acute myocardial infarction (AMI) have a poorer prognosis than their men peers. However, gender differences in elderly patients especially in octogenarians are not fully discussed. We evaluated gender differenes in ogtogenarians patients with AMI in Japan, which is highly progressive aging society.

Methods and Results: We established the multicenter registry to collect data of patients with AMI. 3691 patients enrolled into a registry from 27 hospitals during 2005 and 2009. Among these patients, 755 patients were octogenarians ( age equal or older than 80), and 383 were male and 372 were female. Female was more likely to be older (84.2±3.9 vs 85.7±4.3, p<0.0001) and longer from the onset of symptom to admission, more likely to have heart failure in admission. However, there was no change in the rate of hypertension, dyslipidemia, diabetes between both gender. Primary percutaneous coronary intervention (PCI) was performed at a high frequency in both groups (male vs female, 78.9% vs 75.5%, p=0.28). In patients with AMI female <80 years old had higher in-hospital mortality than male of the same age (male vs female, 4.4% vs 9.5%, p<0.0001), but not in octogenarian patients (male vs female, 14.6% vs 19.9%, p=0.055). In multivariable analysis, female was stronger predictor of in-hospital mortality in non-octogenarian patients (Odds Ratio 2.7, 95%CI 1.6-4.3, p<0.0001), than in octogenarian patients (Odds Ratio 1.4, 95%CI 0.78-2.4, p=0.27).

Conclusions: In octogenarian AMI patients, gender differences of baseline characteristics are not so strong as non-octogenarian patients, and female was not so strong predictor of in-hospital mortality.