Abstract 18170: Impact of Chronic Statin Therapy on Development of Glucose Intolerance and New-onset Diabetes Mellitus in Asian Population

Abstract

Background; There have been several reports that statin therapy is associated with a slightly higher incidence of new-onset diabetes mellitus (DM) or impaired glucose intolerance (IGT). It is still controversial whether the chronic statin therapy is a risk factor of IGT and new onset DM, especially in Asian population.

Methods; We investigated the 13,561 patients (pts) that was glycerate hemoglobin level < 6.0% and fasting glucose level < 124 mg/dL (statin therapy group=4016 and control group=9545). To adjust potential confounders including age, gender, hypertension, hyperlipidemia, chronic kidney disease, hyper/hypo-thyroidism, lipid profile, beta-blocker, diuretics, a propensity score matched analysis was performed using the logistic regression model. The primary end-point was the cumulative incidence of new-onset DM, IGT, and impaired fasting glucose (IFG). Also, Multivariable Cox-regression analysis by adjusted by aforementioned variables was performed to determine the impact of statin therapy on the incidence of new-onset DM, IGT, and IFG.

Results; Mean follow-up duration was 534±604 days in all-pt group, and 608±607 days in propensity score matching group. Baseline characteristics was similar between the two groups except hyperlipidemia (11.1% vs. 3.5%, p<0.001). In Kaplan-Meyer curve, there was no difference between the two groups (p=0.501, figure A). Also, in cox-regression analysis performed in all pts, statin therapy was not associated with the increased incidence of primary end-point (figure B).

Conclusions; In our study, there was no clear association with statin therapy and IGT and new-onset DM in a series of cardiovascular pts in Asian population.