Abstract 17954: Visceral Adiposity Index and Serum 25-OH Vitamin D: Insights from the NHANES-III

Abstract

Introduction: 25-OH Vitamin D (VD) deficiency has been linked to dysmetabolism. We sought to explore the relationship of VD deficiency and Visceral Adiposity Index (VAI) which correlates with visceral adipose tissue function. Hypothesis: Is Vitamin D a predictor of visceral adipose tissue function?

Methods: We queried the National Health and Nutrition Examination Survey-III (NHANES-III). Our sample consisted of 3,728 individuals representing 46,407,622 US adults. We excluded subjects with missing data, age <19 and >83 years, hypertension, diabetes, congestive heart failure, stroke, myocardial infarction and BMI <20 and >30 kg/m². Sex-specific VAI was calculated as: VAI (male): [WC/39.68+1.88*(BMI)]*(TG/1.03)*(1.31/HDL) and VAI (female): [WC/36.58+1.89*(BMI)]*(TG/0.81)*(1.52/HDL). [WC=Waist Circumference, BMI=Body Mass Index, TG: Triglycerides, HDL: High Density Lipoprotein Cholesterol]. VAI and VD were divided into two groups at the 75^th percentile and 50^th percentile respectively. Step-wise univaraite and multivariate logistic regression models were built using VD as continuous (logarithmic VD) and categorical variables. All analyses were performed utilizing survey weights to account for the complex survey design of NHANES-III. Stata SE 11.1 was utilized for statistical analysis.

Results: Baseline characteristics and regression models as shown in tables below.

Conclusion: 25-OH-Vitamin D has an inverse relationship with VAI which is a predictor of visceral adipose tissue function.