Abstract 17931: Cystatin C, Hemoglobin A1c and Insulin Resistance and its Effect on Mortality Among Non-diabetic Nationally Representative Population

Abstract

Introduction: No prior study has evaluated the association between Cystatin C (CysC), a renal marker of atherosclerosis, with homeostasis model assessment-estimated insulin resistance (HOMA-IR) and hemoglobin A1c (HbA1c) and its effect on mortality among non-diabetics free of prevalent cardiovascular disease (CVD).

Methods: We evaluated 5,769 participants of the National Health and Nutrition Examination Survey ΙΙΙ over a median follow up of 14 years. To assess the correlation between CysC, HbA1c and HOMA-IR, Pearson’s correlation co-efficients were calculated. Multivariate adjusted Cox-proportional hazard analyses were carried out to evaluate their independent association as well as interactions for overall, CVD and coronary heart disease (CHD) mortality.

Results: See Tables 1 and 2 and Figure 1.

Conclusion: Although both elevated CysC and HbA1c>5.7 portend worse prognosis, their combination does not provide added prognostic value over presence of high CysC alone.