Abstract 17905: Association of Microalbuminuria and Cystatin C for Mortality Among Nationally Representative Population with Normal Creatinine-based Estimated Glomerular Filtration Rate

Abstract

Background: Limited information is available about the combined effect of higher Cystatin C (CysC) levels and presence of microalbuminuria (MA) for mortality prediction among nationally representative participants free of prevalent cardiovascular disease (CVD) and with normal creatinine-based estimated glomerular filtration rate (eGFR, >=60 ml/min/1.73m²).

Methods: We evaluated 5,141 participants of National Health and Nutrition Examination Survey ΙΙΙ over a median follow up of 14 years. Adjusted Cox-proportional hazard analyses were performed to evaluated the combined predictive value of MA and high CysC (>90^th percentile of population distribution) for all-cause mortality, all CVD and hard coronary heart disease (CHD) mortality.

Results: See Table 1 and Figure 1.

Conclusion: MA and CysC are independent predictors of mortality; however, presence of both MA and high CysC portends significantly worse prognosis than presence of either of them alone among participants free of prevalent CVD and with normal eGFR.