Abstract 17812: Carotid Intima Media Thickness and Cardiovascular Disease Risk Reclassification
Background: Carotid intima-media thickness (CIMT) has shown to be associated with cardiovascular disease (CVD) events. In this study, we assessed whether CIMT reclassifies individuals in a population of healthy adults free of clinical CVD beyond the traditional risk assessment tools.
Methods: The study cohort comprised of 6500 adults from the Multi-ethnic Study of Atherosclerosis. Multivariate Cox proportional Hazard analysis was performed to evaluate both common carotid CIMT and Internal carotid CIMT as predictors of all CVD events and hard coronary heart disease (CHD) events. Analytic properties of carotid intima media thickness were assessed using c-statistics, receiving operating curve characteristics and likelihood ratio test. Net Reclassification Improvement (NRI) index was calculated by comparing regression models incorporating traditional CVD risk factors with and without common carotid and internal carotid CIMT.
Results: Highest tertiles of both common and internal CIMT were predictive of all CVD events while only the highest tertile of internal CIMT was predictive of CHD events (table 1). Table 2 illustrates analytic properties of CIMT and NRI.
Conclusion: Both common and internal CIMT do not add to risk restratification beyond the traditional risk factors despite being independent predictors of CVD or CHD events.
- © 2012 by American Heart Association, Inc.